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These predicted targets were further integrated with additional experimental information on the relevance of enzymes for viral replication to subselect candidates for experimental testing

Effects on vulnerable populations (pregnant women, children, immunocompromised individuals) are unknown

However, repeated or vigorous shaking can physically break the peptide bonds, a process called mechanical shearing

Mechanistically, bacterial flagellin induces a proinflammatory response by activating Toll-like receptor-5 (TLR5) in macrophages, and the presence of flagellin antibodies in pancreatic biopsies of individuals with type 2 diabetes lends support to this mechanism in humans

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