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Description
Mice lacking the protein BAD (BCL-2-associated Agonist of Cell Death) [47], have reduced cellular glucose metabolism [48]

Proteomics data demonstrated that 92 proteins were upregulated in PQS-treated RAW264.7 macrophages compared with non-treated RAW264.7 macrophages (Supplementary Fig

Abbreviations AD: Alzheimers disease APP/PS1: Amyloid precursor protein/presenilin 1 A: -amyloid BDNF: Brain-derived neurotrophic factor CNS: Central nervous system CSF: Cerebrospinal fluid DAMPs: Danger-associated molecular patterns GDNF: Glial cell-derived neurotrophic factor ICAM-1: Intercellular cell adhesion molecular-1 IL-2: Interleukin 2 MT1: Melatonin receptor 1 MT2: Melatonin receptor 2 NFTs: Intracellular neurofibrillary tangles NF-B: Nuclear factor kappa B NSCs: Neural stem cells PAMPs: Pathogen-associated molecular patterns PECAM-1: Platelet endothelial cell adhesion molecular-1 REM: Rapid eye movements SCN: Suprachiasmatic nucleus SGZ: Subgranular zone SVZ: Sub-ventricular zone TLRs: Toll like receptor References Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ

Am J Physiol Gastrointest Liver Physiol 2021;320:G24157
Voutilainen S, Nurmi T, Mursu J (2006) Carotenoids and cardiovascular health

For example, the localized infusion of BDNF to neighboring areas of the CNS could be globally administered with specific drug delivery systems, using nanomaterials that are capable of crossing the BBB
