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PGC-1 initiates mitochondrial biogenesis as a transcriptional coactivator after translocation from the cytoplasm to the nucleus upon phosphorylation by AMPK, and binds to transcription factors including PPAR, PPAR, and CREB (75, 76)
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doi: 10.1007/s10072-011-0902-z 44
After furin cleavage, the S2 site requires an additional proteolytic step to facilitate the fusion of viral envelope with host cell membrane
She has been applying betamethasone dipropionate 0.05% cream, once daily for up to four weeks at a time, to the affected areas
