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Natural compounds like midazolam, vitamin B12, metformin, Cangrelor, and hesperidin have also shown anti-inflammatory effects in preclinical MIRI models, often by modulating macrophage polarization or inhibiting inflammatory pathways like NF-B (Xu et al., 2024)

The equivalent number of cells were seeded in a 12-well plate and treated with AFB 1 for 48 h

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Moreover, lactate-mediated H3K18 lactylation positively regulates the transcription of tumor necrosis factor superfamily member 9 (TNFSF9), further linking lactate metabolism with M2 polarization events [171]

[DOI] [PubMed] [Google Scholar] 29.Seiler A, Schneider M, Forster H, Roth S, Wirth EK, Culmsee C, et al

External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor