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In parallel, we performed gene set variation analysis (GSVA) to compare the level of NRF2 activity in our bulk RNA-sequencing datasets to curated NRF2 gene target signatures consisting of 108 genes from human NSCLC and 207 genes from lymphoblastoid cells (Supplementary Table 1) [30, 31]

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As the ASCO panel noted, Although proof of benefit has not been provided, data suggestive of benefit support that 3 approaches (scrambler therapy, acupuncture, and exercise) may diminish established CIPN symptoms and appear to be reasonably safe. Nonetheless, they emphasised the need for further research to clarify the effectiveness of these therapies, acknowledging that while the evidence remains inconclusive, these interventions may still provide relief for some patients

The same mutation has been found in genetically unrelated individuals suggesting that this is a true hot spot area for mutation