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Description
However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

571 RekelandIGFossALandeAKtoridou-ValenISrlandKHolsenMet al

10.1002/advs.202404496 265 WanglerS.PeroglioM.MenzelU.BennekerL

Early intervention potentially most impactful for callus formation and revascularization

These cells are naturally drawn to sites of injury through SDF-1/CXCR4 signaling, where they release growth factors like VEGF and HGF

doi: 10.1016/S0166-2236(99)01443-5
