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doi:10.5897/AJB10.925 Wang M, Sun J, Xue F, Shang F, Wang Z, Tan T (2012a) The effect of intracellular amino acids on GSH production by high-cell-density cultivation of Saccharomyces cerevisiae

Moreover, Nrf2 also upregulates the expression of the xCT anti-porter system that favors the further restoration of GSH stocks through the entry into hepatocytes of extracellular cystine and the efflux of intracellular glutamate [154]

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SARS-CoV-2 infection exacerbates this metabolic imbalance and predisposes these patients to the severe pathophysiologies of COVID-19, including the involvement of NETs (neutrophil extracellular traps) and HA overproduction in the lung

These findings by other research groups support our findings which indicated that NTZ suppressed MTX-induced oxidative stress and ER stress and eventually the proapoptotic pathways protecting the liver against MTX toxicity