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The dose of vitamin B12 used in the VISP and NORVIT trials and issues with the design of the VISP trial might have obscured a small but still meaningful benefit to vitamin B12 supplementation (234)

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References 1 Int J Biochem Cell Biol Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I (Ballard et al., 1996)Review describing des(1-3)IGF-I: the N-terminal Gly-Pro-Glu is absent, it binds IGF-binding proteins poorly, and it is generally ~10-fold more potent than IGF-I at stimulating cell hypertrophy and proliferation