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The outcome of the search showed 38 publications between 20012019, which included eight reviews, 10 clinical trials, and three meta-analyses

Although -synuclein is frequently implicated in PD pathogenesis, other proteins such as PTEN induced putative kinase 1 (PINK1), Parkin, DJ-1, leucine-rich repeat kinase 2 (LRRK2) have been strongly linked to familial forms of PD 6,7

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Interestingly, low concentrations of this opioid agonist rather promote phosphorylation at S375 and T379 while a strong phosphorylation of T370 and S375 is observed at higher concentrations (Just et al., 2013)

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The peptide accelerated tendon-to-bone biomechanical and histological recovery at every tested dose and reversed the impairment of healing produced by 6-methylprednisolone (1 mg/kg) co-treatment