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Copper/MYC/CTR1 interplay: a dangerous relationship in hepatocellular carcinoma

Such a system could help define functional subtypes based on pathogenic processes rather than surface phenotype alone

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High GAPDH activity in relation to the activities of the other glycolytic enzymes in the cascade can increase the pool of metabolites of lower glycolysis and funnel glycolytic intermediates towards both serine de novo synthesis and/or the TCA cycle depending on PKM activity, and at the same time reduce the pool of available DHAP/G3P needed for MG production

doi:10.1186/1743-7075-10-2

The first reaction is the formation of the dipeptide -glutamylcysteine (GGC) from the amino acids L-glutamic acid and L-cysteine