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At the drug concentrations produced by weekly dosing, the natural peak-and-trough cycle allows partial receptor resensitization during the trough period

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That brings us to berberine, the supplement nicknamed 'nature's Ozempic.' It is a real plant compound that can modestly help blood sugar and cholesterol, mainly through a different pathway (an enzyme called AMPK), not by acting like GLP-1

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Medication prescriptions are at the discretion of medical providers and may not be suitable for everyone