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Evidence suggests that aberrant activation of lysosomal cathepsins, which play a key regulatory role in trypsinogen activation, may represent an early pathological event in acinar cell injury during the onset of AP

A randomized controlled trial (Phase 1 and 2) examined the efficacy of intracerebroventricular A-DA in PD patients with L-DOPA-related complications

J Cell Biol 217:22912298 Bao L et al (2017) ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells

Therapeutic strategies aimed at inhibiting ferroptosissuch as employing antioxidants or iron chelatorsrepresent promising avenues for attenuating COPD progression

H.et al (2019b)

Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells
