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Lastly, the change from methionine to leucine at the 27th position is believed to help prevent methionine oxidation

doi: 10.1016/J.BCP.2009.08.025 17 Gonzalez-OchoaA

Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate receptor mechanism and biological outcomes

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Angrau 2000, 28, 5764
