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In the case of flavonoids using the X/XO system in the assessment of their antiradical capacity, the antioxidant activity can occur either directly by direct scavenging of radicals or by inhibiting the activities of free radical-generating enzymes such as xanthine oxidase and nitric-oxide synthase

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doi: 10.3109/03602532.2011.558093 McIlwain et al.,2006 McIlwain CC, Townsend DM, Tew KD(2006)Glutathione S-transferase polymorphisms: cancer incidence and therapy Oncogene 25(11):1639-48 Hayes et al.,1995Hayes JD, Pulford DJ.(1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance