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Given the similarities between POEMS syndrome and plasma cell dyscrasias such as multiple myeloma, it could be postulated that the mechanisms in POEMS syndrome causing vitamin B12 deficiency may be similar

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The chemical structure of cyanocobalamin contains the rare mineral cobalt (4.34%), which binds the cyano group and is located in the center of a corrin ring

Rare but severe side effects include: Body-wide itching or swelling

For mild deficiencies due to inadequate dietary intake, oral supplementation with vitamin B12 tablets or capsules may be sufficient

(10) Research has examined how NNMT inhibition affects muscle cell energetics, protein synthesis, and metabolic parameters