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Additionally, intracranial (superior sagittal sinus), portal, and caval hypertension and aortal hypotension were reduced, as were the grossly congested stomach and major hemorrhagic lesions, brain swelling, venous and arterial thrombosis, congested inferior caval and superior mesenteric veins, and collapsed azygos vein

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IKEMA and CANDOR Results from a phase Ib study (NCT02332850) indicated that isatuximab combined with carfilzomib was clinically active in heavily pretreated RRMM patients [72]