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The introduction and standardization of the CPZ model in C57BL/6 mice has made it possible to share and compare data from different laboratories to gain a more reliable insight into the molecular and cellular mechanisms underlying de- and remyelination, with particular facilitation for the use of various transgenic mice, which in most circumstances bear a C57BL/6 genetic background

According to a Clinicians Guide in a University of Virginia report published in 2018, the condition may not fully resolve for up to eight weeks, however (8) Neurologic symptoms, like tingling, numbness in hands and feet, or dizziness, generally improve in six to 12 weeks, and severe neurological symptoms, like difficulty walking, may not ever resolve completely

Additionally, ICP6 can phosphorylate eIF2, a key initiation factor, thereby suppressing host protein synthesis and favoring production of viral proteins over cellular functions

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Hofstetter CP, Schwarz EJ, Hess D, Widenfalk J, El Manira A, Prockop DJ, et al