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Published research has proposed and examined several potential mechanisms: Beta-3 Adrenergic Receptor Interactions A substantial body of published research has examined interactions between this GH fragment and beta-3 adrenergic receptors (3-AR) in adipose tissue research models

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doi:10.1024/0300-9831/a000237 Stubbendorff A, Kern S, Rydn L, Skoog I, Samuelsson J

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Additionally, Nampt knockout mice models demonstrated that NAD + depletion in muscle leads to progressive loss of muscle function, while NR treatment restored mitochondrial function and induced muscle remodeling and restoration 255

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