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Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women
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The pain arises either directly from the disease, through invasion or compression of neural structures including spinal nerves, plexuses, and peripheral nerves, or from a consequence of oncological therapies, with one large study attributing pain to the cancer itself in 92.5% of severe cases and to treatment in 20.8% [138]

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