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Adipose tissue-derived free fatty acids (FFAs) impair renal urate excretion via URAT1 upregulation, while hyperuricemia reciprocally induces insulin resistance and endothelial dysfunction through AMPK inhibition and oxidative stress (Xu et al., 2015)

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(66) reported that in vivo data acquired from the anterior cingulate cortex (ACC, voxel size: 2.542cm 3 ) and hippocampus (voxel size: 232cm 3 ) had concentrations of Glu and Gln in the ACC of 11.71.2 and 2.50.8 mM, respectively, while in the hippocampus Glu and Gln were found to be 10.91.4 and 2.20.8 mM, respectively (66)

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