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Use no more than the recommended dosage

In a study in 8 men, ingesting caffeine led to a 13% increase in calorie burning, as well as a 2-fold increase in fat burning much greater effects than they experienced after taking a placebo or beta-blocker (medication for blood pressure and circulation) ( Summary The caffeine in cold brew coffee can increase how many calories you burn at rest

And you shouldnt take berberine if youre pregnant or breastfeeding

10.1097/MCG.0000000000001409 Josephine Nhu Tran, Robert J Wong, Janet S Lee, Tim Bancroft, Ami R Buikema, Jie Ting, Norah Terrault

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It is a relatively safe drug when used at the recommended doses