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doi: 10.1186/s12886-015-0023-1

77 The mechanism of action is supposed to be a selective, heat induced denaturalization of dermal collagen that leads to subsequent reactive synthesis

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Physicians who prescribe unapproved drugs without an Investigational New Drug (IND) application violate federal law and risk medical board sanctions

Additionally, some renal diets for kidney disease also limit specific nutrient quantities to prevent overloading the already-limited filtration function of the kidneys

A UL of 2 grams (2,000 milligrams) daily was recommended in order to prevent most adults from experiencing diarrhea and gastrointestinal disturbances (17)