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The New England Journal of Medicine , 389(6), 514526

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[1] Increased Heart Rate Increased resting heart rate has also been reported with Wegovy

How to reconstitute lyophilized tirzepatide If your compounding pharmacy provides tirzepatide as a lyophilized (freeze-dried) powder rather than a pre-mixed solution, you will need to reconstitute it yourself

In TRIUMPH-1 the pivotal Phase 3 obesity trial, which reported topline results on May 21, 2026 participants on the highest dose lost an average of 28.3% of their body weight (70.3 lbs) at 80 weeks Evidence: Phase 3 RCT, against 2.2% on placebo