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Rat and mouse animal models, developed to study the pesticide exposure effects, especially the neurotoxic effects, have supported the epidemiological link between Parkinsons disease (PD) and agricultural pesticide use

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In any case, the here reported beneficial effects of FOXO4-DRI provide a wide range of possibilities for studying the potential of therapeutic removal of senescence against diseases for which few options are available

Beneficial effects of pioglitazone, a selective peroxisome proliferator-activated receptor- agonist in prenatal valproic acid-induced behavioral and biochemical autistic like features in Wistar rats

In ALS, mutated TDP-43 can disrupt nuclear integrity and hamper the nonhomologous end-joining (NHEJ) pathways crucial for repairing double-strand DNA breaks in neurons