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Preliminary evidence also suggests that tirzepatide may confer cardiovascular benefits by improving lipid metabolism (e.g., lowering LDL cholesterol) and reducing inflammation (e.g., lowering C-reactive protein)

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If tirzepatide is discontinued, the appetite-suppressing effects wear off, making it easier to regain weight unless healthy eating and regular physical activity are maintained

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In contrast, Retatrutide functions as a triple agonist, incorporating glucagon receptor activation alongside GLP-1 and GIP