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doi: 10.1016/j.freeradbiomed.2012.06.042
Other forms, including 5-formyl-THF, are converted to 5-methyl-THF by intestinal mucosa (as the organ most responsible for adding the methyl group and reducing the vitamin) or in a small degree by the liver 887,892
and C.C

Thus, aldose reductase activity consumes NADPH (Figure 4), a critical cofactor necessary for the regeneration of the primary lens antioxidant, glutathione (GSH), from its oxidized form (GSSG)

Vitamin B6 helps maintain healthy testosterone production by limiting oestrogen buildup that can work against testosterone's effects
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