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Rare but serious complications - such as skin rashes, Stevens-Johnson syndrome, thyroid issues, or kidney dysfunction - have been reported [21] [22]

Since both CIPN and hearing loss are dose-related, they occur concurrently in many patients but there is not a clear mechanistic or risk-based relationship between these effects

The role of DHAR proteins in ascorbate regeneration has been demonstrated in tobacco, since DHAR-downregulating tobacco lines show reduced total ascorbate levels, lower dry weight, and diminished photosynthetic efficiency (Chen and Gallie, 2006

Numbing is applied beforehand and pain is very minimal

Cachexia Sarcopenia Muscle 12 , 746768 (2021)

[DOI] [PubMed] [Google Scholar] 61.Thomas S.D., Abdalla S., Eissa N., Akour A., Jha N.K., Ojha S., Sadek B