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The seminal 4S study published in 1994 explored the impact of simvastatin on all-cause mortality among people with previous myocardial infarction or angina and hyperlipidemia (mean baseline BMI, 26)

Still, both have important warnings

The core issue is not failure

Traditional dieting can also backfire for some people by slowing metabolism and setting up the cycle of losing and regaining

Some peoples genes make them more likely to store fat deep in the belly rather than in safer subcutaneous places

Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist originally approved for type 2 diabetes, has emerged as one of the most effective weight loss medications available