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8 Weight Loss and GLP-1RA Therapy The use of all types of GLP-1RAs, to a greater or lesser extent, leads to body weight reduction due to decreased appetite and promoting feelings of satiety and stomach fullness, resulting in a lower calorie intake from food

K.et al (2009)

For that reason, much of the care management strategies employed when prescribing GLP-1 medications borrow from evidence-based obesity care management and diabetes care management

[50] [51] [52] The FDA approved tirzepatide based on evidence from nine clinical trials of 7,769 participants with type 2 diabetes, of whom 5,415 received tirzepatide

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The long-acting IUB288 glucagon analogue has been used to identify GcgR-mediated: reductions in body weight, food intake, and circulating cholesterol