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animal studies have identified two regions as particularly important

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Avoid skipping meals entirely, as this can exacerbate both headaches and other GLP-1 side effects

However, exposure to heat or extended time outside the fridge can reduce effectiveness

Abnormal accumulation of A proteins is thought to be associated with neurodegenerative processes that may lead to disruption of communication between neurons, causing an inflammatory response and ultimately neuronal damage and death (Hardy and Allsop, 1991)