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Description
It inhibits the NLRP3 inflammasome in renal macrophages by enhancing AMPK-mediated autophagy, thereby reducing caspase-1 activation and the secretion of IL-1/IL-18, which are key mediators of tubulointerstitial injury (107)
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(1) Overview Epithalon is a synthetic tetrapeptide, also known as the AEDG peptide, composed of amino acids Ala-Glu-Asp-Gly
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In contrast, PEG-fused animals showed some return of locomotor function beginning at 35 days PO (Single Cut, 77.5 9.9
