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Bests Ratings are under continuous review and subject to change and/or affirmation

For many patients, this can lead to: Loose or sagging skin Hollow cheeks or temples Increased fine lines and wrinkles Crepey skin texture Loss of facial definition Deflated appearance in areas like the breasts or buttocks These changes are not caused by the medication itself as much as they are the result of rapid weight loss

Affecting approximately 50% of patients with diabetes, DN is predominantly characterized by distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction, often resulting in diabetic foot ulcers and lower-limb amputations

JAMA Intern Med 2022

As clinical experience with these drugs accumulated, their capacity to produce significant weight loss became widely known, and off-label use for obesity and weight management grew substantially

Research shows that GLP-1 decreases gastric emptying and intestinal motility through both peripheral and central nervous system mechanisms