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They were then randomized to either continue tirzepatide or switch to placebo for another 52 weeks

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By the end of the week, appetite is down, nausea is up, and it is suddenly clear that eating well on this medication is less about willpower and more about choosing foods that match what your body can tolerate

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As of 2026, retatrutide is not FDA-approved

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To prevent this, focus on sustainable dietary changes and regular physical activity

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Whilst both may influence glucose metabolism and body weight, they operate through entirely different mechanisms

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Schoorlemmer RM, Peeters GM, van Schoor NM, Lips P

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