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The various DPP-4 inhibitors do not form a homogenous class of molecules, and they show different interactions with the active site of the enzyme molecule

10.1016/j.kint.2022.10.030 [DOI] [PubMed] [Google Scholar] 87

We also collected pre-index-date eGFR values to compute the baseline eGFR slope

And if you don't eat, you lose weight

So each time they use the pen, it gives them the dose thats required. However, many GLP-1 users have noticed that after their four expected doses, theres still medication in their injection pen, providing them with possibly a fifth dose, or whats been coined the golden dose by GLP-1 users

The authors report no other conflicts of interest in this work
