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Hydrolytic Stress: Exposure to acidic, and alkaline conditions accelerates peptide bond cleavage

(PDF) Cusin, C., Dillon, D.G., Belleau, E., Normandin, M.D., Petibon, Y., El-Fakri, G., Dhaynaut, M., Hooker, J., Kaptchuk, T., McKee, M., Hayden, E., Meyer, A., Jahan, A., Origlio, J., Ang, Y-S., Brunner, D., Kang, M., Long, Y., Fava, M.*, Pizzagalli, D.A.* (2025)

This early checkpoint provides a practical opportunity to reassess treatment strategies rather than continuing ineffective interventions

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Transdermal estrogen does not carry this risk
