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By this dual approach, it amplifies the benefits seen with GLP-1 agonists by targeting both incretin pathways (Rizvi and Rizzo 2022)

NF-B: nuclear factor kappa-B

For a 200-pound person, that means 90-145 grams of protein each day

Combined with the GLP-1-mediated improvements in insulin sensitivity and the GIP-mediated changes in lipid metabolism, the triple agonist creates conditions under which the liver clears accumulated fat at rates never before observed in clinical settings

This pharmacokinetic modification allows for once-weekly subcutaneous administration, improving patient adherence compared to shorter-acting agents