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Seek immediate medical attention for warning signs including: severe or persistent vomiting, inability to keep fluids down for more than 24 hours, severe abdominal pain (especially if radiating to the back), abdominal distension with absence of stool or gas, or yellowing of the skin/eyes with right upper abdominal pain

However, the natural hormones may be insufficient in people who struggle with their weight

This has led to widespread off-label use of diabetes GLP-1 doses

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A 2025 analysis found that GLP-1 agonists given for diabetes were associated with a reduced risk of substance use among hundreds of thousands of United States Veterans and a 2024 examination of over 500k patients 4 Qeadan, F., McCunn, A., & Tingey, B