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Description
Additional trials are also underway in participants with type 1 diabetes targeting diverse pathways including oxidative stress, using nicotinamide adenine dinucleotide phosphate oxidase (Nox)-1/4 inhibitors, and the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, using bardoxolone (NCT03366337, NCT03550443) [84, 85]

Additionally, if youre living with obesity and struggling to lose weight, GLP-1s effectively support clinically significant weight loss of more than 10% of body weight

2), which was sustained after 3 years of treatment [33]

[6] Tirzepatide (Mounjaro): up to 15 mg once weekly for type 2 diabetes, and up to 15 mg once weekly for chronic weight management (marketed as Tirzepatide)

10.1371/journal.pone.0061965 59 SirohiS.SchurdakJ

Current Drug Metabolism , 16
