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retatrutide mechanism triple agonist glp-1 gip glucagon LY3437943, a novel glucagon, GIP, and receptor for glycemic control and weight loss: From discovery to clinical proof of concept How Does Retatrutide Work? Triple
Description
Exendin-4 DPP-4 resistance due to Gly at position 2

Abnormal gastric slow waves, severe symptoms of gastroparesis and less improvement with gastric electrical stimulation is seen in the absence of ICC

Voltage-dependent K+ channels in pancreatic cells: role, regulation and potential as therapeutic targets

Lancet Diabetes Endocrinol (2020) 8(5):37791

Higher doses can cause loose stool and gut cramps
Appetite suppression can lead to lower caloric and electrolyte intake, and if you combine that with exercise or caffeine, you raise the odds of a palpitation