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Mechanical property analysis indicated that when compressed by about 0.65 mm, MNs could withstand approximately 1.85 N of force, while the MNs/GLP-1RAs@NPs-WYRGRL could withstand less pressure, about 1.6 N (Fig

Horm Metab Res 36:755760 [DOI] [PubMed] [Google Scholar] Chu ZL, Carroll C, Alfonso J, Gutierrez V, He H, Lucman A, Pedraza M, Mondala H, Gao H, Bagnol D, Chen R, Jones RM, Behan DP, Leonard J 2008 A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release

4 However, this protective mechanism leads to pathological changes in the setting of prolonged exposure to nutrient overload

Finally, due to the small number of events occurring across studies, the results for severe gastrointestinal AEs and discontinuation outcomes were particularly sensitive to small differences in events and allow for broad comparisons only

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