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Description
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FLOW trial findings show semaglutide is associated with sustained improvements in quality of life in chronic kidney disease (CKD).
Promotes appetite reduction and improved fullness response*

What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

In a prespecified analysis of the SELECT trial, semaglutide demonstrated significant reductions in cardiovascular mortality and HF hospitalizations for patients with HF and ASCVD
Clinical trials show cumulative weight reduction of 1522% over 68 weeks at higher doses