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Significance statement ![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

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While the overall frequency of liver enzyme elevations across the over 1,400 participant safety database of danuglipron is in-line with approved agents in the class, a single asymptomatic participant in one of the dose-optimization studies experienced potential drug-induced liver injury which resolved after discontinuation of danuglipron

GLP-1 medications replicate na

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