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Description
GLP-1 medications work through two primary mechanisms within the brain: Strengthening the blood-brain barrier, which protects against harmful substances 28 Reducing neuroinflammation through specialized brain cells called microglia and astrocytes 29 GLP-1 receptor signaling enhances neuron growth and survival 28

In the brain, GLP-1 secreted from intestinal cells can be absorbed into the brain, and GLP-1 secreted from neurons remains in the CSF (Holscher, 2012)

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This hormone helps regulate food intake and blood sugar control by promoting a feeling of fullness, decreasing appetite, and slowing down gastric emptying
