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Semaglutide at the 2.4mg weekly dose produced 13.7 percent body weight loss at 72 weeks in the STEP 1 trial

Despite the link, the role of insulin abnormalities in PD remains contentious, with little difference found between patients with PD and healthy controls in peripheral insulin resistance, quantified using a hyperinsulinemic-euglycemic clamp [71]

Last reviewed: June 19, 2026 Last updated: June 19, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Many GLP-1 users report reduced appetite, smaller meals, and digestive changes

Their use is currently contraindicated for patients with atypical anorexia nervosa, bulimia nervosa, or subthreshold bulimia nervosa, as GLP-1RAs could worsen the restrictive eating behaviors common in these conditions

Increased Body Weight Associated With Prolactin Secreting Pituitary Adenomas: Weight Loss With Normalization of Prolactin Levels