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Implications for Glucagon Family Receptor Poly-Agonists: GLP-1R Agonism Is Sine Qua Non Over the past few years, novel class B1 GPCR poly-ligands, i.e., compounds that bind more than one receptor simultaneously, have joined the ranks of the classic GLP-1RAs (GLP-1R mono-agonists), such as exenatide, liraglutide, semaglutide, dulaglutide, etc

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*Correspondence: Brittany Johnson, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Key Benefits: Supports natural GLP-1 activity* for appetite control and metabolic support

Notably, there is a significant representation of studies involving children, particularly those with obesity-related conditions like obese children with elevated body mass index (BMI) or healthy children with overweight and obesity [10,11,44]

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