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ESC Heart Failure 11(2):649661 Jalil JE, Gabrielli L, Ocaranza MP, MacNab P, Fernndez R, Grassi B, Jofr P, Verdejo H, Acevedo M, Cordova S et al (2024) New mechanisms to prevent heart failure with preserved ejection fraction using glucagon-like peptide-1 receptor agonism (GLP-1 RA) in metabolic syndrome and in type 2 diabetes: a review

Liraglutide (Victoza, Saxenda) : Approved for type 2 diabetes (1.8 mg daily) and chronic weight management (3.0 mg daily)

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Doctors prescribe them as weekly injections

Improved Formulations and Delivery Methods Other advancements include longer-acting formulations that may eventually require less frequent dosing, improved delivery methods that enhance comfort and convenience, and combination approaches that pair GLP-1 therapy with complementary treatments

Pancreatic beta cells synthesize neuropeptide Y and can rapidly release peptide co-transmitters