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As GEP44 acts directly on muscle tissue, while its effects on islets require concomitant Y1-R antagonism, activation of Y1-R expressed in muscle tissue may ultimately prove to be a critical factor in reducing serum glucose levels, alongside any potential effects on insulin secretion and glucagon release

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For GLP-1 users, this means better gym performance, improved recovery, and direct muscle support

PubMed 29

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Holst, a pioneer in GLP-1 research, has been studying its metabolic effects for decades