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Patients with LN were excluded from such studies due to the potential necessity of acute immunosuppression ( Recently, we have published a pilot study in patients with LN on stable immunosuppressive treatment and non-immunosuppressive treatment with RAASi to whom a 10-mg dose of empagliflozin was added, obtaining a 50% reduction in residual proteinuria with minimal changes in eFGR and with few side effects ( GLP-1RA Glucagon-like peptide one receptor agonists (GLP-1RA) is a class B G protein-coupled receptor expressed in the pancreas and central nervous system but is also present in other organs such as the gut, kidneys, lungs, liver, heart, muscle, and peripheral nerves

Usually this is circumvented by carefully increasing the dose, suggesting the dose escalation regimen for SAR425899 was inappropriately selected for this study
