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GLP-1 medications such as semaglutide and tirzepatide are commonly used to support appetite regulation and metabolic balance

Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion

New-generation 5-HT4 agonists have high selectivity for 5-HT4 receptors, with little affinity for other serotoninergic and other classes of receptors [53]

A phase 3 program is registered on public trial registries under program names including TRIUMPH (obesity) and TRANSCEND (type 2 diabetes)

0.25 mg Beginning Injectable Semaglutide The 0.25 mg once-weekly dose is commonly used for the first four weeks to introduce treatment gradually and improve gastrointestinal tolerability

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