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For example, medical conditions were self-reported, whereas Bessette and Anderson were unable to measure all trial exclusion criteria with accurate temporality, which may underestimate the proportion excluded. Bessette said that primary care providers should consider screening for depression, liver function, and concomitant use of medications that delay gastric emptying before prescribing medications like GLP-1 receptor agonists

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Availability of compounded semaglutide and tirzepatide is subject to applicable federal and state compounding rules, provider approval, and pharmacy availability